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Chair, Biomedical Engineering
Professor, Biomedical Engineering
Associate Member, Otolaryngology
Associate Member, Electrical Engineering
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BioMedical Engineering Department
Duff Medical Building 3775 University Street, Room 308 Montréal, QC H3A 2B4 |
Tel: +1-514-398-6738
Fax: +1-514-398-7461 E-mail: henrietta.galiana at mcgill.ca |
Dr. Galiana's research interests focus on signal processing and the
modelling of control strategies for the orientation of eyes and head,
and related issues of platform coordination and sensory fusion.
Theoretical predictions are tested in the vestibular clinic for
patient evaluation, and by porting to biomimetic robot systems.
Dr. Galiana's work in the field of sensorimotor
control involves modelling with topologically relevant circuits. Her
work on nystagmus analysis has led to automated methods for the
classification of switching segments, applicable to any eye reflex and
to other non-linear signals in breathing or spectroscopy. These
pre-classification algorithms have allowed the unmasking of unexpected
reflex dynamics and led to new hypotheses for both gaze control and
arm control. These are demonstrated in real robotic platforms and
suggest much simpler strategies for prostheses.
Director, Graduate Program, Biomedical Engineering
Professor, Biomedical Engineering
Professor, Physiology
Associate Member, School of Physical & Occupational Therapy
Associate Member, Mechanical Engineering
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BioMedical Engineering Department
Duff Medical Building 3775 University Street, Room 309 Montréal, QC H3A 2B4 |
Tel: +1-514-398-6737
Fax: +1-514-398-7461 E-mail: robert.kearney at mcgill.ca Web site |
Human Motor Control. This research addresses the role of
the peripheral neuromuscular system in the control of posture and
movement. System identification methods are used to address three main
questions: (1) What are the mechanical properties of human joints and
how do they vary under normal physiological conditions? (2) What
mechanisms are responsible for generating the mechanical behavior;
what are the relative roles of intrinsic muscle properties and reflex
mechanisms? (3) What role do these mechanical properties play in the
control of posture and movement?
Biomedical System Identification and Signal Analysis. This research focuses on the development of tools and techniques for the analysis of biomedical signals and system and their application to clinically relevant problems . The emphasis is on practical methods for the identification of linear-time-varying and nonlinear systems within a continuous-time, nonparametric context. Current application areas are: (1) human motor control; (2) respiratory monitoring for apnea detection/prediction in the pediatric recovery room; and (3) automated decision support for electronic fetal monitoring.
Bioinformatics. Proteomics is a relatively new field that
focuses on the large-scale study of the location and relative
abundance of proteins within cells and organs. Dr. Kearney's research
aim is to develop algorithms that improve the accuracy, throughout and
sensitivity of proteomics measurements and assist in inferring
biological significance from them. There are three main areas of work:
(1) the deployment and operation of a robust, secure information
technology infrastructure to support the acquisition, analysis and
interpretation of proteomics data; (2) the development of CellMapBase,
a custom database and Web-based application for the distributed
acquisition and analysis of proteomics data; and (3) the elucidation
and evaluation of new algorithms and tools to assess, validate and
improve the efficiency and accuracy of protein identification and
abundance measurement.
Professor, Surgery
Professor, Biomedical Engineering
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Orthopedic Surgery Department
Montreal General Hospital 1650 Cedar Avenue, Room A2156 Montréal, QC H3G 1A4 |
Tel: +1-514-934-1934 ext. 44558
Fax: +1-514-934-8261 E-mail: jdbobyn at hotmail.com |
Dr. Bobyn studies engineering and biomaterials issues related to
the design and function of joint replacement implants, particularly
for the hip and knee. His research is divided into two main areas.
The first relates to the surgical implantation of materials and implants in experimental animals for the study of the hard tissue response. This includes the biological fixation of porous materials by bone ingrowth and the long-term adaptive bone remodelling that results from the alteration of peri-implant stress distribution. An area of intense focus at the moment is the use of locally delivered bisphosphonates for enhancing peri-implant bone formation.
The second relates to mechanical studies of biomaterials and implant constructs, materials characterization, static and fatigue loading, implant stability and wear performance. The primary focus at the moment is the wear resistance of hard-on-hard hip bearings, both ceramic-ceramic and metal-metal. This involves both pin-on-disk and hip simulator studies of new and existing material combinations.
Director, Artificial Cells and Organs Research Centre
Professor Emeritus, Physiology
Professor Emeritus, Medicine
Professor Emeritus, Biomedical Engineering
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Artificial Cells and Organs Research Centre
McIntyre Medical Sciences Building 3655 Promenade Sir William Osler, Room 1004 Montréal, QC H3G 1Y6 |
Tel: +1-514-398-3514
E-mail: artcell.med at mcgill.ca Web site |
Artificial cells; modified hemoglobin; blood substitutes; immobilized
enzymes/cells/microorganisms; microencapsulation of enzymes/ cells/ microorganisms/adsorbents/drugs;
biodegradable control delivery systems; biomaterials; artificial liver;
artificial kidney; hemoperfusion; enzyme engineering.
Interdisciplinary research on above topics based on biotechnology,
chemical engineering, chemistry, physiology and medicine.
Professor, Biomedical Engineering
Professor, Neurology and Neurosurgery
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Magnetic Resonance Imaging (MRI)
Montreal Neurological Institute 3801 University Street, Room WB315 Montréal, QC H3A 2B4 |
Tel: +1-514-398-4227
Fax: +1-514-398-2975 E-mail: louis at bic.mni.mcgill.ca Web site |
Dr. Collins works on the use of computerized image
processing techniques such as non-linear image registration and
model-based segmentation to automatically identify structures within
the human brain and to quantify anatomical variability. He
investigates neuroscientific
applications of three dimensional (3D) digital image processing
methods for disease diagnosis, prognosis and image-guided surgery.
These techniques are applied to large databases of magnetic resonance (MR) data from normal subjects to quantify normal anatomical variability in pediatric, young adult and elderly populations. The techniques have also been used to automatically quantify global and regional brain atrophy in MS patients and to look at morphological changes associated with diseases such as schizophrenia and Alzheimer's dementia.
In image-guided neurosurgery (IGNS), these techniques provide the
surgeon with computerized tools to assist in interpreting anatomical,
functional and vascular image data, permitting the effective planning
and execution of minimally invasive neurosurgical procedures.
Automated atlasing is essential in IGNS for thalamotomy and
pallidotomy in the treatment of Parkinson's disease, or temporal-lobe
depth-electrode implantation in the diagnosis of epilepsy, since
tissue targets in these procedures cannot be viewed directly on MR.
Computerized atlasing minimizes trauma to the patient and allows
resection of the smallest amount of brain tissue necessary for
effective therapeutic treatment.
Professor, Neurology and Neurosurgery
Professor, Medical Physics
Professor, Biomedical Engineering
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McConnell Brain Imaging Centre
Montreal Neurological Institute 3801 University Street, Room WB2 Montréal, QC H3A 2B4 |
Tel: +1-514-398-8926
Fax: +1-514-398-8948 E-mail: alan at bic.mni.mcgill.ca Web site |
3-D NeuroImaging of Brain Function (PET, SPECT) and Brain Anatomy (MRI,
CT); Kinetic Analysis of Tracer in Brain using PET; 3-D Brain Atlases of
Human, Rat and Monkey using computerized segmentation; Imaging Physics
of PET Scanners and; Functional neuroanatomy of normal cognitive processing.
(P.E.T. = Positron Emission Tomography; SPECT = Single Photon Emission
Computed Tomography.)
Associate Professor, Biomedical Engineering
Associate Professor, Otolaryngology
Associate Member, Obstetrics & Gynecology
Associate Member, Electrical Engineering
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BioMedical Engineering Department
Duff Medical Building 3775 University Street, Room 302 Montréal, QC H3A 2B4 |
Tel: +1-514-398-6739
Fax: +1-514-398-7461 E-mail: robert.funnell at mcgill.ca Web site |
Middle-ear mechanics. The overall objective is to address
key clinical issues related to hearing loss. The specific objectives
are to (1) obtain more accurate and more detailed information from
screening and diagnostic tests, especially in infants; and (2) design
better techniques for repairing middle ears. The approach is to do
both experimental work and computer modelling. The experimental work
is complemented by experimental data from our collaborators in Antwerp.
The interpretation and synthesis of the experimental data
is addressed using finite-element models.
Three-dimensional modelling of complex natural structures. The objective is to develop innovative approaches to the creation of computer-based 3-D models of complex natural objects, for the purposes of both visualization and simulation. The emphasis is on the creation of high-quality finite-element models for complex structures consisting of multiple heterogeneous substructures.
3-D models for teaching. The current emphasis is on
the use of interactive 3-D models for teaching anatomy, and on
the use of haptics (force feedback) for endoscopy training.
Assistant Professor, Biomedical Engineering
Assistant Professor, Neurology & Neurosurgery
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BioMedical Engineering Department
Duff Medical Building 3775 University Street, Room 304 Montréal, QC H3A 2B4 |
Tel: +1-514-398-2516
Fax: +1-514-398-7461 E-mail: christophe.grova at mcgill.ca Web site |
Dr. Grova investigates multimodal data fusion to characterize
brain mechanisms and especially epileptic activity. His research
project aims at developing methods to appropriately combine multimodal
data in order to detect additional information that could be missed by
considering each modality individually. A typical challenge is to
combine modalities directly measuring neuronal activity with high
temporal resolution with other modalities indirectly measuring
the same function with high spatial resolution, through
hemodynamic processes for instance. The project will involve the
integration of three promising functional modalities:
(1) Simultaneous ElectroEncephaloGraphy (EEG) - MagnetoEncephaloGraphy (MEG) acquisitions, measuring directly on the scalp electric and magnetic components of signals generated by neurons synchronously active (at a ms scale).
(2) Simultaneous EEG - functional Magnetic Resonance Imaging fMRI acquisitions to measure, within the whole brain at a second scale, hemodynamic responses that correlate with signals detected on scalp EEG.
(3) Simultaneous EEG - Near InfraRed Spectroscopy (NIRS) acquisitions to measure local changes in oxy- and deoxy-hemoglobin at the time of signals detected on scalp EEG, by exploiting absorption properties of infrared light within brain tissues using optic fibres placed on the surface of the head.
The principal clinical application of this project will be to
combine these three modalities using multimodal data fusion techniques
to characterize brain regions involved during epileptic activity.
Associate Professor, Biomedical Engineering
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BioMedical Engineering Department
740, Dr. Penfield Avenue, Room 6206 Montréal, QC H3A 1A4 |
Tel: +1-514-398-7676
Fax: +1-514-398-1790 E-mail: david.juncker at mcgill.ca Web site |
Micro and Nanotechnologies supported the integration ,
miniaturization, and large scale parallelization of microelectronics
with an exponential growth for over 40 years that has come to be known
as Moore's law. This exponential growth has fuelled the "digital
revolution". The power of miniaturization and parallelization, enabled
by microtechnologies, has started to bear on the life sciences, and
already revolutionized them, by means of DNA microarrays and high
throughput DNA sequencing running millions of biochemical reactions in
parallel, as opposed to a single reaction at a time just a few years
ago.
Dr. Juncker is designing and developing micro and nanobioengineering
technologies – with a strong focus microfluidic systems – and are
using these technologies for miniaturizing and parallelizing
proteomics and cell biology. His goal to emulate the parallelization of
DNA microarrays and sequencers, and enable systematic and quantitative
approach to biological experimentation for protein analysis and cell
biology in particular. Systematic and quantitative biology will in
turn help accelerate the study, the understanding, and the
modelization of cells and of diseases such as cancer as complex
(biological) systems.
Associate Professor, Biomedical Engineering
Associate Member, Physics
Associate Member, Microbiology & Immunology
Adjunct Professor, Institute of Molecular Biophysics, Jackson
Laboratory, Bar Harbor, Maine
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BioMedical Engineering Department
Duff Medical Building 3775 University Street, Room 310 Montréal, QC H3A 2B4 |
Tel: +1-514-398-8372
Fax: +1-514-398-7461 E-mail: jay.nadeau at mcgill.ca Web site |
Dr. Nadeau specializes in the use of fluorescent nanocrystals and
novel genetically-encoded probes for labeling and imaging of cultured
cells. Her group synthesizes and characterizes nanoparticles of
various materials, clone and express membrane proteins, and labels and
images live cells.
Dr. Nadeau's work has two main branches: one, to characterize the basic photophysics of nanoparticle probes for fluorescence, CT, and MR imaging. This work includes steady-state and time resolved spectroscopy, electron microscopy, XPR, particle sizing, and blinking analysis. Collaborators are at McGill, the University of Maine and USC.
The second branch involves investigation of the biological effects
of nanoparticles, including their toxicity to the environment and
their possible use as anti-cancer drugs. Collaborators are with the
Radiation Physics group at McGill, and at UCSB.
Professor, Biomedical Engineering
Professor, Neurology and Neurosurgery
Professor, Medical Physics Unit
Professor, Radiology
Associate Member, Electrical Engineering
Coordinator, McConnell Brain Imaging Centre
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Montreal Neurological Institute
3801 University Street, Room WB316 Montréal, QC H3A 2B4 |
Tel: +1-514-398-1929
Fax: +1-514-398-2975 E-mail: bruce.pike at mcgill.ca Web site |
Dr. Pike investigates magnetic resonance imaging (MRI) methods and
applications for basic and clinical neuroscience research. As his
primary focus, he measures the physiological modulations that are
involved in neuronal activation using methods termed functional MRI.
fMRI can detect changes in blood oxygenation and tissue perfusion with
a high temporal and spatial resolution. It also provides a powerful
tool for studying brain physiology and pathophysiology. Recently, Dr.
Pike used his novel functional MRI methods to determine, for the first
time, the quantitative relationship between regional cerebral blood
flow and oxygen consumption in the cortex over a broad range of
activation and inhibition conditions in both healthy subjects and
epilepsy patients. Dr. Pike has also developed a quantitative MRI
technique, termed magnetization transfer (MT) imaging, that probes the
magnetic interaction between macromolecules and water. Using MT
imaging, his group has revealed focal pathology in multiple sclerosis
(MS) patients that precedes the development of conventional MRI
detected MS lesions by up to 2 years. Other areas of active research
in Dr. Pike's lab include diffusion imaging, white matter fibre
tractography, relaxometry, neuropsychiatric lupus imaging, fMRI of
lexical ambiguity, and molecular MRI.
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BioMedical Engineering Department
Duff Medical Building 3775 University Street, Room 311 Montréal, QC H3A 2B4 |
Tel: +1-514-398-3676
Fax: +1-514-398-7461 E-mail: satya.prakash at mcgill.ca Web site |
The primary research interest of this laboratory is in several
innovative areas of artificial cells, microencapsulation, cell
therapy, tissue engineering, nanomedicine, regenerative medicine,
biomaterials, drug delivery, bacterial cell therapy, medical device
engineering, and other biomedical technology developments. The
research is focused on the development of new medical treatment
strategies including novel cell and drug-based therapies.
Specifically, the research team is investigating cholesterol lowering formulations, fatty liver therapeutics, therapeutic protein delivery, novel therapies for neurodegenerative diseases, inflammatory bowel diseases, wound healing, and formulations for use in colon and breast cancers. The research team is also investigating basic mechanisms for the design of artificial organ substitutes such as artificial kidney, liver and skin.
In recent years, the research team has contributed to the advancement and development of bioengineered, target specific, and controlled-release delivery systems. These systems are focused on designing artificial cell microcapsules to encapsulate mammalian cells, bacterial cells and other microorganisms, enzymes, small peptides, DNA and other active drugs. Such biotherapeutics are capable of targeting specific sites and are used in our research to design formulation for clinical applications.
In addition, the research team is developing systems that
integrate bioengineering and tissue engineering principals, with gene
and cell therapies, to design new therapeutic products. The present
engineered formulations and devices have been applied in numerous
areas including biomedicine, bioengineering, industry and clinical
settings.
Professor, Biomedical Engineering
Professor, Faculty of Dentistry
Associate Member, Montreal Heart Institute
Associate Member, Sainte-Justine Hospital
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BioMedical Engineering Department
Duff Medical Building 3775 University Street, Room 313 Montréal, QC H3A 2B4 |
Tel: +1-514-398-8129
Fax: +1-514-398-7461 E-mail: maryam.tabrizian at mcgill.ca Web site |
Dr. Tabrizian's research programme is focused on surface and
biointerface, and the modification of the biomaterials surface to make
them more attractive for biological environment. The surface
modifications are mostly based on biological and chemical methods to
improve the biointerface interactions at cellar and/or molecular
levels. This involves the following ongoing projects:
