Maryam Tabrizian

Associate Professor - Department of Biomedical Engineering

Cross appointment between Faculty of medicine and Dentistry

Chercheure-Nationale FRSQ 2006-2011

Chercheure-boursière FRSQ 2001-2006

Associate Member: Montreal Heart Institute and St Justine Hospital

Director of Centre for Biorecognition and Biosensors

Duff Medical Building
3775 University Street Room 313
Montreal, Qc  H3A 2B4
maryam.tabrizian@mcgill.ca
Tel: (514) 398-8129
Fax: (514) 398-7461

Ph.D.
University P. et  M. Curie (France) in 1990
Postdoctoral fellowship
Center for Sciences and Engineering of Macromolecules at Laval University

RESEARCH INTERESTS

Our inability to predict and control biological phenomena, such as protein adsorption and cellular interactions with artificial interfaces, often result in an inappropriate host response to the biomaterials. In addition, contemporary advances in the biomaterials field are starting to shift focus towards personalized medicine, in particular with the advent of high-throughput and microfluidic methodologies for cell sorting, as well as gene and protein expression profiling. Therefore, with the growing interest in using new biomaterials in regenerative-/nano-/personalized medicine, the development of viable biointerfaces, as well as fundamental understanding and control of biointerfacial properties are becoming the main factors driving the investigation and development of new biomaterials.

The design and development of novel interfaces for improved interactions with biologics is the overall objective of my research. Of particular importance are techniques that permit in-situ and real-time analysis of the dynamics of surface processes, such as biomolecule adsorption, specific antibody-antigen recognition, and cell-surface interactions. Examples include: 1) Development of multifunctional nanoscale interfaces via self-assembly of polysaccharide (sugar), where our laboratory is one of the global leaders in this field. Our pioneer work was highlighted in Nature, New Scientist, and Angewandte Chemie, resulting in many original and high impact papers over the past 10 years. We demonstrated – for the first time – the direct deposition of sugar-based nanocoatings onto damaged arteries not only to protect against thrombogenesis, but also enhance the healing process and prevent restenosis. Another relevant outcome of this work was the successful application of our approach as a simple and effective method to enhance the magnetic resonance imaging (MRI) contrast and develop biocompatible sugar-based nanoparticles that can penetrate 3X deeper in biological tissue than other reported counterparts. The sugar-based nanocoatings were also used for the development of universal red blood cells (highlighted in The Economist). Moreover, our expertise in developing integrated microfluidics platforms for proteomics and genomics resulted in successful implementation of many generations of microfluidics systems for real-time, parallel and sandwich immunoassays. The originality of our work involves the use of antibody-conjugated magnetic beads as substrates to reduce non-specific adsorption as well as the use of quantum dots with a well-designed biointerface to achieve a sensitivity of the detection in the range of 100 femtomolar for biomolecular detection. Further, we developed biointerfaces compatible with a label-free Surface Plasmon Resonance Imaging (SPRi) for the detection of biomolecular interactions on fully automated digital microfluidic platforms. In addition to a patent, many papers published underline the novelty of our approach applied to the detection of disease-specific biomarkers, as well as pathogen and bio-weapons identification.

The main and common approach in the research axes described above is the utilization of various surface modification technologies including physical techniques, microfabrication, or chemisorption such as LbL assembly on various templates. Interdisciplinary teamwork is essential for fulfilling the aforementioned research activities. As a rational outgrowth for the oncoming years, we will address new challenges based on the recent development in materials processing and control of nanoscale surface properties to further modulate the biointerfacial properties for their applications in personalized medicine.

PUBLICATIONS

2011

P. O. Bagnaninchi^*, C. Holmes, N. Drummond, J. Daoud, M. Tabrizian (2011), “Two-dimensional and three-dimensional viability measurements of adult stem cells with optical coherence phase microscopy”, J Biomedical Optics. 16, 086003.

L. Malic, M. G. Sandros, M. Tabrizian*, (2011) “Designed Biointerface Using Near Infra-Red Quantum Dots for Ultrasensitive Surface Plasmon Resonance Imaging Biosensors”, Anal Chem 83(13):5222-9.

F. Azari, M. G. Sandros, M. Tabrizian*, (2011), “Self-Assembled Multifunctional Nanoplexes for Gene Inhibitory Therapy”, Nanomedicine, 6(4):669-80.

J. Fatisson, S. Mansouri, D. Yacoubi, Y. Merhi, M. Tabrizian (2011), “Modeling Time Dependency Dissipation Factor Versus Frequency for Determination of Surface-Induced Platelet Activation». Journal of Royal Society Interface. doi:10.1098/rsif.2010.0617 Published online.

S. Mansouri, Y. Merhi, F. M. Winnik, M. Tabrizian* (2011), “Layer-by-Layer assembled nanocoating strategy on red blood cells for immunocammouflage: A step towards the production of universal blood”, Biomacromolecules, 12(3):585-592.

J. Daoud, M. Petropavlovskaia, J. Patapas, C. Degrandpré, R. DiRaddo, L. Rosenberg, M. Tabrizian* (2011), “Long-Term In Vitro Human Pancreatic Islet Culture Using Three Dimensional Microfabricated Scaffolds”, Biomaterials, 32(6):1536-42.

L. Malic, T. Veres, T, M. Tabrizian* (2011), “Nanostructured digital microfluidics for enhanced surface plasmon resonance imaging”. Biosens Bioelectron. 26:2053-59.

J. Daoud, L. Rosenberg, M. Tabrizian* (2011), “Pancreatic Islet Culture and Preservation Strategies: Advances, Challenges, and Future Outlook”, Cell Transplantation, 19:1523-1535.

2010

 Critical Review: T. Fatanat-Didar, M. Tabrizian* (2010), “Adhesion based detection, sorting and enrichment of cells in microfluidic Lab-on-Chip devices”, Lab on a Chip, c0lc00130a [Epub ahead of print].

Invited Review: Nicolas Duceppe & M. Tabrizian* (2010), “Advances in using chitosan-based nanoparticles for in vitro andin vivo drug and gene delivery”, Expert Opin. Drug Deliv. Published on line © 2010 Informa UK, Ltd. ISSN 1742-524710.

C. Tkaczyk, O. L. Huk, F. Mwale, J. Antoniou, D. J. Zukor, A. Petit, M. Tabrizian*, (2010), “Significance of elevated blood metal ion level in patients with metal-on-metal prostheses: An evaluation of oxidative stress markers”, The Open Orthopaedics Journal, 4:221-7.

J. Daoud, L. Rosenberg, M. Tabrizian* (April 2010), “Pancreatic Islet Culture and Preservation Strategies: Advances, Challenges, and Future Outlook” Cell Transplant. 2010 Aug 17. [Epub ahead of print]

C. Tkaczyk, O. L. Huk, F. Mwale, J. Antoniou, D. J. Zukor, A. Petit, M. Tabrizian*, (2010), “Effect of chromium and cobalt ions on the expression of antioxidant enzymes in human U937 macrophage-like cells”, J Biomed Mater Res. 94(2):419-25.

C. Tkaczyk, O. L. Huk, F. Mwale, J. Antoniou, D. J. Zukor, A. Petit, M. Tabrizian*, (2010), “Investigation of the toxicity of Cr(III): A Proteomic Approach to determine the interactions of bovine and human serum proteins with Cr(III) complexes”, J Biomed Mater Res A. 94(1):214-22.

Z. S. Haidar, R. C. Hamdy, M. Tabrizian* (2010), “Biocompatibility and safety of a hybrid core-shell nanoparticulate OP-1 delivery system intramuscularly administered in rats”. Biomaterials 31(10):2746-54.

J. Daoud, M. Petropavlovskaia, L. Rosenberg, M. Tabrizian* (2010), “The effect of extracellular matrix components on the preservation of human islet function in vitro”, Biomaterials, 31(7):1676-82.

Z. Haidar, M. Tabrizian, R. Hamdy* (2010), "A hybrid rhOP-1 delivery system enhances new bone regeneration and consolidation in a rabbit model of distraction osteogenesis", Growth Factors, 28(1):44-55.

L. Malic, D. Brassard, T. Veres, M. Tabrizian* (2010), “Detection of biochemical assays in digital microfluidic LOC devices”, Lab on a Chip, 10(4):418-31.

2009

C. Tkaczyk, O. L. Huk, F. Mwale, J. Antoniou, D. J. Zukor, A. Petit, M. Tabrizian*, (July 2009), “Investigation of the toxicity of Cr(III): A Proteomic Approach to determine the interactions of bovine and human serum proteins with Cr(III) complexes”, J. Biomed. Mat. Res., In Press.

(Invited) Z. Haidar, R. Hamdy, M. Tabrizian* (July 2009) “Recombinant BMP Delivery for Bone Regeneration and Repair, Part A: Current Challenges in BMP Delivery”, Biotechnology letters miniReviews, In Press.

Z. Haidar, R. Hamdy, M. Tabrizian* (July 2009) “Recombinant BMP Delivery for Bone Regeneration and Repair- Part B: Delivery Systems for BMPs in Orthopaedic and Craniofacial Tissue Engineering”, Biotechnology letters miniReview, In Press.

M. Behrendt, M. G. Sandros, R. A. McKinney, K. McDonald, J. Kriz, E. Przybytkowski_, M. Tabrizian, D. Maysinger* (2009), “Uptake and cellular distribution of InGaP/ZnS nanoparticles is enhanced by oleic acid treatment, Journal of Nanomedicine, In Press.

(Invited) S. Mansouri, J. Fatisson, Y. Merhi, F. M. Winnik, M. Tabrizian* (2009), “Silencing Red blood cells recognition towards antibody-Anti A by mean of polyelectrolytes LbL assembly in a 2-D model system”, Langmuir, [Epub ahead of print].

X. D. Hoa, M. Tabrizian, A. G. Kirk* (2009), “Rigorous Coupled-Wave Analysis of Surface Plasmon Enhancement from Patterned Immobilization on Nano-Gratings”, Journal of Sensors, available on-line.

A. L. Hillberg, C. Holmes, M. Tabrizian*, (2009) “Effect of Genipin Cross-linking on the Cellular Adhesion Properties of Layer-by-Layer Assembled Polyelectrolyte Films”, Biomaterials [Epub ahead of print].

(Invited) S. Mansouri, F. M. Winnik, M. Tabrizian* (2009), “Modulating the release kinetics through the control of the permeability of the LbL assembly: A review”, Expert Opinion on Drug Delivery, 6(6):585-597.

Z. S. Haidar, F. Azari, R. C. Hamdy, M. Tabrizian* (2009), “Modulated release of OP-1 and enhanced pre-osteoblast differentiation using a core-shell nanoparticulate system”, J Biomed Mater Res A, [Epub ahead of print].

X. D. Hoa, A.G. Kirk and M. Tabrizian* (2009), “Enhanced SPR Response from Patterned Immobilization of Surface Bioreceptors on Nano-gratings” Biosensors & Bioelectronics, 24(10):3043–3048.

S. Faghihi, F. Azari, J. A. Szpunar, H. Vali, M. Tabrizian* (2009), “Titanium crystal orientation as a tool for the improved and regulated cell attachment”, J Biomed Mater Res A, [Epub ahead of print].

L. Malic, T. Veres, M. Tabrizian*, (2009), “Biochip functionalization using electrowetting-on-dielectric digital microfluidics for surface plasmon resonance imaging detection of DNA hybridization”, Biosens & Bioelectron, 24(7):2218-24.

N. Duceppe, M. Tabrizian* (2009), “Factors influencing the transfection efficiency of ultra low molecular weight chitosan/hyaluronic acid nanoparticles”, Biomaterials, 30(13):2625-31.

L. Malic, T. Veres, M. Tabrizian* (2009), “Two-dimensional droplet-based surface plasmon resonance imaging using electrowetting-on-dielectric microfluidics”, Lab-on-a Chip, 9(3):473-5. 

C. Tkaczyk, O. L. Huk, F. Mwale, J. Antoniou, D. J. Zukor, A. Petit, M. Tabrizian^* (2009), ^“Cr(III), Cr(VI), and Co(II) ion interactions with simulated physiological fluids: determination of the molecular composition of organic-inorganic nanostructures formed in RPMI 1640&DMEM high glucose media”. Biomaterials, 30(4):460-7.

2008

G. Sydow-Plum, Z. S. Haidar, Y. Merhi, M. Tabrizian* (2008), “Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies”, Materials, 1 25-43.

G. Sydow-Plum, M. Tabrizian* (2008), “Review of stent coating strategies: clinical Insights”, Materials Science and Technology, 24(9): 1127-43.

A. Dorris, K. Douglas, M. Tabrizian, C. Barrett*, (2008) “Control of DNA incorporation into nanoparticles with poly-L-lysine multilayers”, The Canadian Journal of Chemistry, 86(12):1085-94.

X. D. Hoa, M. Martin, A. Jimenez, J. Beauvais, P. Charette, A. Kirk, M. Tabrizian* (2008), “Fabrication and Characterization of Patterned Immobilization of Quantum dots on Metallic Nano-gratings”, Biosens & Bioelectron, 24(4):976-81.

S. Faghihi, F. Azari, A. P. Zhilyaev, J. A. Szpunar, H. Vali, M. Tabrizian* (2008), “Effect of crystal size and orientation of substrates on cell adhesion: implication for medical implants”, International Journal of Modern Physics •22, (18 & 19) 3069-81

B. Thierry*, F. M. Winnik, Y. Merhi, H. Griesser, M. Tabrizian (2008), “Biomimetic Hemocompatible Coatings through Immobilization of Hyaluronan Derivatives on Metal Surfaces”, Langmuir, 24(20):11834-41.

M. G. Sandros_, C. B. Sarraf, M. Tabrizian* (2008), “Prodrugs in Cardiovascular Therapy, Invited Review”, Molecules, 14:13(5):1156-78.

Z. Haidar, R. Hamdy, M. Tabrizian* (2008), “A novel OP-1 delivery system for the potential acceleration of regenerate formation and consolidation in distraction osteogenesis”, Bone, 43 S38-S75: A36.87.

D. Brassard, L. Malic, F. Normandin, M. Tabrizian, T. Veres* (2008), “Water-oil core-shell droplets for electrowetting-based digital microfluidic devices”. Lab-on-a Chip, 8(8):1342-9.

M. G. Sandros_, C. B. Sarraf, M. Tabrizian* (2008), “Prodrugs in Cardiovascular Therapy, Invited Review”, Molecules, 14;13(5):1156-78.

M. Mandu-Hrit, E. Seifert, M. Kotsiopriftis, D. Lauzier, T. Haque, C. Rohlicek, M. Tabrizian, R. C. Hamdy* (2008), “OP-1 injection increases VEGF expression but not angiogenesis in a rabbit model of distraction osteogenesis", Growth Factors;26(3):143-51.

F. Azari, H. Vali, J-L. Guerquin-Kern, T-D Wu, A. Croisy, S. K. Sears, M. Tabrizian*, M. D. McKee* (2008), “Intracellular precipitation of hydroxyapatite mineral and implications for pathologic calcification”, J. Stuctural Biology, 162:468–479.

M. Herrmann, T. Veres, M. Tabrizian* (2008), “Quantification of Low-Picomolar Concentrations of TNF-a in Serum Using the Dual-Network, Microfluidic ELISA Platform”, Anal. Chem., 80(13):5160-7.

J. Fatisson, Y. Merhi, M. Tabrizian* (2008), “Quantifying blood platelet morphological changes by dissipation factor monitoring in multilayer shell”, Langmuir, 24(7):3294-9.

F. Burel^*, L. Poussard, M. Tabrizian^*, Y. Merhi, C. Bunel (2008), “The Influence of isocyanurate content on the bioperformance of hydrocarbon-based polyurethanes” J. Biomat. Sci. -Polymer edition, 19(4):525-40.

Z. S. Haidar, R. C. Hamdy, M. Tabrizian* (2008), “Core-shell hybrid nanoparticles through layer-by-layer assembly of alginate and chitosan on liposomes for protein delivery: Characterization and release kinetics”, Biomaterials, 29(9):1207-15.

K. Douglas, C. Piccirillo, M. Tabrizian* (2008), “Cell-Line Dependent Internalization Pathways and Intracellular Trafficking Determine Transfection Efficiency of Nanoparticle Vectors”, European Journal of Pharmaceutics, 68:676-687.

(Invited) A. L. Hillberg, M. Tabrizian* (2008), “Biomolecule imprinting: Developments in mimicking dynamic natural recognition systems”, Innovation et technologie en biologie et médecine (ITBM)-RBM 29:89–104. 

(Invited) L. Marcotte, M. Tabrizian* (2008), “Sensing surfaces: Challenges in studying the cell adhesion process and the cell adhesion forces on biomaterials”, Innovation et technologie en biologie et médecine (ITBM)-RBM 29:77–88.

2007

(Invited) M. Sandros, M. Tabrizian*, (2007), “Drug-Eluting Stents Devices: Clinical Relevance and Perspective”, Fundamentals about stents II, Ed: N. Chakfé, B. Durant, J.G. Kretz, pp147-160.

L. Malic, B. Cui, T. Veres, M. Tabrizian* (2007), “Enhanced Surface Plasmon    Resonance Imaging Detection of DNA Hybridization on Periodic Gold Nanoposts”, Opt. Let., 32(21) 3092-94.

M. Sandros, M. Behrendt, D. Maysinger, M. Tabrizian* (2007), “InGaP@ZnS-enriched chitosan nanoparticles: A new versatile fluorescent probe for deep tissue imaging”, Advanced Functional Materials, 17(18):3724-30.

M. Herrmann, E. Roy, T. Veres, M. Tabrizian* (2007), “Microfluidic ELISA on non-passivated PDMS chip using magnetic bead transfer inside dual networks of channels”, Lab-on-a-Chip, 7:1546-52.

D. Dziong, P. Bagnaninchi, R. E. Kearney, M. Tabrizian* (2007), “Nondestructive On-line in-vitro Monitoring of Pre-Osteoblast Cell Proliferation within Micro-Porous Polymer Scaffolds”, IEEE-Transaction of Nanoscience, 6(3), 349-258.

X. D. Hoa, A.G. Kirk, M. Tabrizian* (2007), “Toward Integrated Surface Plasmon Resonance Biosensors: A Review of Recent Progress”, Biosens & Bioelectron, 23:151-160.

S. Faghihi, F. Azari, A. P. Zhilyaev, J. A. Szpunar, H. Vali, M. Tabrizian* (2007) “Cellular and molecular interactions between MC3T3-E1 pre-osteoblasts and nanostructured titanium produced by high-pressure torsion”, Biomaterials, 8(27):3887-95.

S. Faghihi, F. Azari, A. P. Zhilyaev, J. A. Szpunar, H. Vali, M. Tabrizian* (2007), “Nanostructured titanium produced by high pressure torsion increases the expression of fibronectin and vinculin to promote the pre-osteoblast adhesion and growth”, Advanced Materials, 19 (8):1069-1073.

2006

M. Mandu, T. Haque, D. Lauzier, M. Kotsiopriftis, F. Rauch, M. Tabrizian, J. Henderson, R.C. Hamdy* (2006), “Early injection of OP-1 during distraction osteogenesis accelerates new bone formation in rabbits”. Growth Factors, 24(3):172–183.

A. Hillberg, M. Tabrizian* (2006), “Biorecognition on living cell through layer by layer deposition of polyelectrolytes:in situ hybridization and cell viability studies”. Biomacromolecules, 7(10):2742-50.

K. Douglas, C. Piccirillo, M. Tabrizian* (2006), “Effects of Alginate Inclusion on the Vector Properties of Chitosan-Based Nanoparticles”, Controlled Release Systems, 115:354-361.

S. Faghihi, F. Azari, H. Li, M. R. Bateni, J. A. Szpunar, H. Vali, M. Tabrizian* (2006), “The significance of crystallographic texture of titanium alloy substrates on pre-osteoblast responses”, Biomaterials, 27(19):3532-9.

M. Gravel, R. Vago, M. Tabrizian* (2006), “Use of Natural Coralline Biomaterials as reinforcing and foaming agent for developing novel hybrid biomatrices: Microarchitectural and mechanical studies”, Tissue Eng, 12(3):589-600.

M. Herrmann, T. Veres, M. Tabrizian^* (2006), “Development of a microfluidic platform for parallel ELISA in stop-flow conditions with internal magnetic mixing”, Lab-on-a-Chip, 6(4):555-60.

C. Fleury, A. Petit, F. Mwale, J. Antoniou, D. J. Zukor, M. Tabrizian^*, O. L. Huk^* (2006), “Effect of cobalt and chromiumions on human MG-63 osteoblasts in vitro: Morphology, cytotoxicity, and oxidative stress”, Biomaterials, 27(18):3351-60.

T. Haque, M. Mandu, F. Rauch, D. Lauzier, M. Tabrizian, R.C. Hamdy * (2006), “Immunohistochemical Localization of BMP Signaling Smads During Long-Bone Distraction Osteogenesis”, J. Histochem. Cytochem, 54(4):407-15.              

2005

S. D. Carrigan, G. Scott, M. Tabrizian* (2005), “Reducing non-specific adhesion on cross-linked hydrogel platforms for real-time immunoassay in serum”, Langmuir, 21(26):12320-6.

S. Faghihi, M. R. Bateni, F. Azari, J. A. Szpunar, H. Vali, M. Tabrizian*, (2005), “The Role of Crystallographic Texture of Ti-6Al-4V alloy on Cell Attachment and Proliferation”, Materials Science Forum, 495-97:705-10.

M. Gravel, T. Gross, R. Vago, M. Tabrizian^* (2005) “Responses of mesenchymal stem cell to chitosan-coralline composites microstructured using coralline as gas forming agent”, Biomaterials, 27(9):1899-906.

B. Thierry, Y. Merhi, J. Silver, M. Tabrizian* (2005), “Biodegradable Membrane-Covered Stent from Chitosan-Based Polymers”, J. Biomed. Mater. Res. Part-A, 75(3):556-66.

J. P. St-Pierre, M. Gauthier, L. P. Lefebvre, M. Tabrizian* (2005), “Three–dimensional growth of differentiating MC3T3-E1 pre-osteoblastson porous scaffolds”, Biomaterials, 26(35):7319-28.

S. D. Carrigan, G. Scott, M. Tabrizian* (2005), “Rapid three-dimensional biointerfaces for real-time immunoassay using rhIL-18BPa as a model antigen”, Biomaterials, 26: 7514-7523.

S. D. Carrigan, G. Scott, M. Tabrizian* (2005), “Real-time QCM-D immunoassay through oriented antibody immobilisation using cross-linked hydrogel biointerfaces”, Langmuir, 21, 5966-5973.

B. Thierry, S. Faghihi, L. Torab, B. Pike, M. Tabrizian* (2005) “Magnetic Resonance Signal-Enhancing Self-Assembled Coating for Endovascular Devices”, Advanced Materials, 17(7): 826-830.

B. Thierry, C. Tkaczyk, P. Kujawa, F. M. Winnik, L. Bilodeau, M. Tabrizian^* (2005), “Novel Drug Delivery Platform through combined Prodrug Approach and Self-Assembled Multilayers”, J. Am. Chem. Soc., 127(6):1626-7.

L. Poussard, F. Burel, J.P. Couvercelle, Y. Merhi, M. Tabrizian*, C. Bunel* (2005), “In vitro thrombogenicity investigation of new water dispersible polyurethanes anionomers”, J. Biomater. Sci. Polymer Edn 16, 335-351.

A. Senechal, C. Catuognou, M. Tabrizian* (2005), “Initial Adhesion Stages of Enterococcus faecalis to Medical Grade Polymers: Qualitative Characterization and Quantification using a DNA-based Fluorescence Assay”, J. Biomater. Sci. Polymer Edn 16, 115-129.

K. Douglas, M. Tabrizian* (2005), “New Approach to the Preparation of Alginate-Chitosan Nanoparticles as Gene Carriers – Part I: Effect of Experimental Parameters on Particle Formation”, J. Biomater. Sci. Polymer Edn 16, 43-56.

2004

P-O. Bagnaninchi, M. Dikeakos, T. Veres, M. Tabrizian (2004), “Complex Permittivity Measurement as a New Non-invasive Tool for Monitoring in-vitro Tissue Engineering and cell signature through the Detection of Cell Proliferation, Differentiation and Pre-tissue Formation”, IEEE-Transaction of Nanoscience, 3(4): 243-250.

J.-P. St-Pierre, M. Gauthier, L.-P. Lefebvre, M. Tabrizian (2004), “Adhesion Kinetics of MC3T3-E1 Pre-Osteoblasts to Osteoconductive Porous Titanium Scaffolds”, MRS Proc. 823:W12.9.1.

S. D. Carrigan, G. Scott, M. Tabrizian (2004), “Toward Resolving the Challenges of Sepsis Diagnosis”, Clinical Chemistry: 50 (8):1301-14.

A. Sénéchal, S. D. Carrigan, M. Tabrizian (2004), “Probing Surface Adhesion Forces of Enterococcus faecalis to Medical Grade Polymers using Atomic Force Microscopy”, Langmuir, 20:4172-4177.

B. Thierry, F. M. Winnik, Y. Merhi, J. Silver, M. Tabrizian (2004), “Radionuclides-hyaluronan-conjugate thromboresistant coatings to prevent in-stent restenosis”, Biomaterials, 25:3895-3905.

L. Poussard, F. Burel, J.-P. Couvercelle, Y. Merhi, M. Tabrizian, C. Bunel (2004),“Haemcompatibilty of new Ionic polyurethanes: influence of carboxylic group insertion modes” Biomaterials, 25:3473-3483.

2003

B. Thierry, M. Tabrizian (2003), “Biocompatibility and biostability of metallic endovascular implants – states of the art and perspectives”, Journal of Vascular Therapy, 10(4): 807-24.

B. Thierry, F. M. Winnik, Y. Merhi, J. Silver, M. Tabrizian (2003), “Bioactive Coatings of Endovascular Stents based on Polyelectrolyte Multilayer”, Biomacromolecules, 4(6):1564-71.

P-O Bagnaninchi, Maria Dikeakos, Teodor Veres, M. Tabrizian (2003)^, “Towards on line monitoring of cell growth in microporous scaffolds: utilization and interpretation of complex permittivity measurements”, Biotechnology & Bioengineering, 84(3): 343-50.

B. Thierry, F. Winnik, Y. Merhi, M. Tabrizian (2003), “Nanocoatings onto Arteries via Layer-by-Layer Deposition: Towards the In-Vivo Repair of Damaged Blood Vessels”. JACS, 125:7494-95.

P-O Bagnaninchi, Maria Dikeakos, Teodor Veres, M. Tabrizian (2003), “Monitoring of stem cell differentiation using a permittivity responsive biointerface”, MRS proc 773: N7.12.1-6.

N. Ma, A. Petit, O. Huk, L’H Yahia, M. Tabrizian (2003), “Safety Issue of Re-sterilization of Poly-urethane Electrophysiology Catheters: A Cytotoxicity Study”, JBS-Polymer Edn., 14(3):213-26.

2002

N. Ma, A. Petit, O. L. Huk, L’H. Yahia, M. Tabrizian (2002), “Cytotoxic reaction and TNF-a Response of Macrophages to Polyurethane Particles”, JBS-Polymer Edn, 13(3):257-272.

B. Thierry, Y. Merhi, L. Bilodeau, Christine Trépanier, M. Tabrizian (2002), “Nitinol Versus Stainless Steel Stents: Acute Thrombogenicity Study In An Ex Vivo Porcine Model”, Biomaterials, 23:2294-3005.

S. Lerouge, M. Tabrizian, W. Wertheimer, M. Marchand, L’H Yahia (2002), “Safety of plasma-based sterilization: surface modification of polymeric medical devices induced by SterradÒ and PlazlyteÒ processes”, Bio-medical Mat & Eng, 12:3-13.

C. Demers, M. Tabrizian, A. Petit, R. Hamdy, L’H Yahia (2002), “Characterization of the controlled release of transforming growth factors bet-1 from coral particles”, JBMR 59:403-410.

L’H Yahia, R. Hernandez, S. Rhalmi, S. Turenne, F. Prudhommeaux, M. Tabrizian (2002), “A biocompatibility evaluation of porous nickel titanium in hard tissue”, SMST Proc., 353-359.

B. Thierry, Y. Merhi, C. Trépanier, L. Bilodeau, L’H. Yahia, M. Tabrizian (2002), “Blood compatibility of Nitinol compared to Stainless Steel”, SMST Proc, 285-290.

C. Demers, R. Hamdy, K. Corsi, F. Chellat, M. Tabrizian, L’H Yahia (2002), “Natural Coral Exosketon as a graft substitute: a Review”, Bio-Medical Mat. & Eng.12(1):15-35.

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ABSTRACTS AND CONFERENCE PRESENTATIONS: LAST THREE YEARS

J. Daoud, L. Rosenberg, M. Tabrizian, “Promotion of Pancreatic Islet Adhesion and Viability Through Specific 2-D Cell-Substrate Interactions In Vitro”, CBS, May 2007, Canada.

Z. Haidar, F. Azari F, R. Hamdy, M. Tabrizian, “In vitro characterization and cytotoxic effect of a liposome-based drug delivery system incorporating alternating L-b-L assembly of polyelectrolytes for craniofacial distraction osteogenesis”. CBS 2006, May 2006, Canada.

J. Fatisson, Y. Merhi, M. Tabrizian, “Détermination de la Morphologie de Plaquettes sanguines aux moyens de la technique d’Autoassemblage électrostatique couche par couche et de la Microbalance à Quartz avec suivi de la Dissipation d’énergie”, Colloque Jacques Cartier, Lyon, France, December 2006.

L. Marcotte, Y. Merhi, M. Tabrizian, “Utilisation de la microscopie à force atomique pour déterminer la force d’adhésion”, Colloque Jacques Cartier, Lyon, France, December 2006.

X. D. Hoa, A.G. Kirk, M. Tabrizian, “SPR Biointerface for Time-Effective Detection of Sepsis Biomarkers”, IEEE-CAMP Conference, Sept. 2006, Canada.

X. D. Hoa, A.G. Kirk, M. Tabrizian, “Increased SPR Biointerface Sensitivity by Surface Corrugations and Patterned Immobilisation for Online Biomarker Detection”, NanoBio 2006, June 2006, France.

M. Herrmann, T. Veres^, M. Tabrizian^, “Utilization of magnetic micro-beads in a stop-flow microfluidic ELISA”, NanoBio 2006, June 2006, France.

K. Douglas, C. Piccirillo, M. Tabrizian^, “Cellular Uptake of Alginate-Chitosan Nanoparticles for Transfection”, CBS, May 2006, Canada.

X. D. Hoa, A. G. Kirk, M. Tabrizian^, “Enhanced SPR Biointerface Sensitivity via Nano Surface Corrugations and Patterned Immobilization for Rapid Sepsis Biomarker Detection”, CBS, May 2006, Canada.

M. Herrmann, T. Veres, M. Tabrizian, “Utilization of magnetic micro-beads in a stop-flow microfluidic ELISA”, CBS, May 2006, Canada.

Z. Haidar, F. Azari, R. Hamdy, M. Tabrizian, “L-b-L assembly of polymers on a liposome-based BMP-7 delivery system for craniofacial distraction osteogenesis”, CBS, May 2006, Canada.

G. Plum, Y. Merhi, L. Bilodeau, M. Tabrizian, “Chitosan-PEO as a Coating Material for Stents and its Potential as a Drug Delivery System”. CBS, May 2006, Canada.

S.Faghihi, F. Azari, H.Vali, J.A.Szpunar and M.Tabrizian, “Effects of CP-titanium grain size on the mouse pre-osteoblast attachment”, THERMEC 2006 International Conference, July 2006, Vancouver, Canada

S.Faghihi, F.Azari, H.Vali, J.A.Szpunar and M.Tabrizian “Preparation and characterization of nano-grain size commercially pure titanium: a potential material as dental implants”, MRS, April 2006, San Francisco, USA.

M. Tabrizian, A. Hillberg, “Hybridization of oligonucleotides through Layer-by-Layer Nanocoating of living cells”, PacifiChem, December 2005, USA.

M. Tabrizian, K. Douglas, J.L. Guerquin-Kern, C. Piccirillo, H. Vali, “Correlative Ionic and Transmission Electron Micros copies imaging for studying the cellular internalization of polysaccharide-based nanoparticles”, PacifiChem, December 2005, USA.

D. Dziong, P.-O. Bagnaninchi, R. E. Kearney, M. Tabrizian, “A Non-destructive Measurement of Cell Differentiation within Micro-porous Polymer Scaffolds using CPM”, CBS, May 2005, Canada.

K. Douglas, T.-D. Wu, J.-L. Guerquin-Kern, A. Croisy, C. Piccirillo, M. Tabrizian, “Studies of the intra-cellular fate of alginate-chitosan nanoparticles using NanoSIMS”, CBS, May 2005, Canada.

S. Carrigan, G. Scott, M. Tabrizian, “Hydrogel Platforms for Generic Real-Time Immunoassay”, CBS, May 2005, Canada.

M. Mandu, R. Hamdy, M. Tabrizian, “polyELECTROLYTE COATED LIPOSOMES AS protein delivery SYSTEM for bone engineering”, CBS, May 2005, Canada.

D. Dziong, P. Bagnaninchi, R. Kearney, M. Tabrizian, “Low-frequency Complex Permittivity Measurement: A Non-destructive Evaluation Method For In-vitro Tissue Growth Within Micro-porous Polymer Scaffolds”, SFB, April 2005. 

A. Hillberg, M. Tabrizian, “Layer-by-layer polyelectrolyte cell encapsulation and its potential use in anti-sense oligonucleotide delivery”, SFB, April 2005.

S. Faghihi, F. Azari, M. Bateni, J. Szpunar, H. Vali, M. Tabrizian, “A Prospective Study To Improve Osseointegration Of Cp- Titanium Considering Its Crystallographic Texture”, SFB, April 2005

M. Mandu, E. Seifert, J. Henderson, M. Tabrizian, R. Hamdy, “BMP-7 Accelerates Bone Formation in Distraction Osteogenesis”, 83rd General Session & Exhibition of International Association for Dental Research (IADR), Maryland, March 2005, USA.

S. Faghihi , R. Bateni , F. Azari , J. A. Szpunar, H. Vali, M. Tabrizian, “Responses of MC3T3 Cells to Crystallographic Texture of Titanium Alloy”, MRS fall meeting, November 2004, USA.

J-P. St-Pierre, M. Gauthier, L-P. Lefebvre, M. Tabrizian, “MC3T3-E1 Pre-Osteoblasts Differentiation Through Interactions with Porous Titanium Scaffolds”, MRS fall meeting, November 2004, USA.

K. Douglas, C. Piccirillo, M. Tabrizian, “Development of Alginate-Chitosan Nanoparticles for Non-Viral Cell Transfection”, Entretien Jacques Cartier, October 2004, Canada. 

M. Mandu, M. Kawaguchi, M. Tabrizian, R. Hamdy,  “SMAD signalling in distraction osteogenesis”, ”. Entretien Jacques Cartier, October 2004, Canada. 

D. Dziong, P. Bagnaninchi, R. Kearney, M. Tabrizian, “A non-destructive method for the in-vitro measurement of tissue growth within micro-porous polymer scaffolds”. Entretien Jacques Cartier, October 2004, Canada. 

C. Fleury, A. Petit, F. Mwale, J. Antoniou, D. J. Zukor, M. Tabrizian, O. L. Huk, “Effect of cobalt and chromium ions on osteoblasts in vitro”, Combined ORS, August 2004, Canada.

C Tkaczyk, A Petit, F Mwale, J Antoniou, D. J. Zukor, M Tabrizian, O. L. Huk, “Heme oxygenase-1 protein expression is stimulated by cobalt ions in human U937 macrophages”, Combined ORS, August 2004, Canada.

L. Poussard, J.-P. Couvercelle, O. Lesouhaitier, M. Tabrizian, Y. Merhi, C. Bunel, “Biocompatibility of water dispersable ionic PU based on HTPB”, MACRO 2004, 40th IUPAC World Polymer Congress, Paris, France, July 4-9, 2004

A. Sénéchal, S. D. Carrigan, M. Tabrizian, “Quantification of Enterococcus faecalis Adhesion Forces to Medical Grade Polymeric Surfaces Using AFM”, WBC, May 2004, Australia.

K. L. Douglas, M. Taheri, M. Tabrizian, “Non-Viral Cell Transfection Using Alginate-Chitosan Nanoparticles”, WBC, May 2004, Australia.

S. D. Carrigan, P. Prince, G. Scott, M. Tabrizian, “Biointerface for real-time detection of Human Cytokine Biomarkers by QCM and SPR”, WBC, May 2004, Australia.

B.Thierry, F. Winnik, Y. Merhi, L. Bilodeau, and M. Tabrizian^{, “}Non-Viral Transfection of the Vasculature Though Self-Assembled Nanocoatings”, WBC, May 2004, Australia

M. Kawaguchi, M. Mandu, M. Tabrizian, R. Hamdy, “SMAD expression during distraction osteogenesis”, ORS, May 2004.

M. Mandu¹, M. Kawaguchi, M. Tabrizian, R. Hamdy, “Effects of single-dose administration of rhBMP-7 on long bones Distraction Osteogenesis”, ORS, May 2004, USA.

S. D. Carrigan, G. Scott, M. Tabrizian, “Optimisation of Hydrogel biointerface layers used for QCM detection of biomarkers”, Am. Phy. Soc., March 2004, Canada.

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  Book Chapters

G. Plum, M. Tabrizian (2005), Clinical Outcomes of Non Pharmaceutical Stent Coatings, Proceeding of European Society for Vascular Biomaterials, p. 83-102.

K. Douglas, S. Carrigan, M. Tabrizian (2004), Nanobiomaterials perspective and possibilities in nano medicine, invited chapter, in Biomedical Engineering Handbook. Taylor & Francis Ed   pp 26-1 to26-20.

B. Thierry, L. Bilodeau, M. Tabrizian(2003), Encyclopedia of Biomedical Engineering , Stents, 1403-1411, Mercel Dekker Edn.

B. Thierry, M. Tabrizian, Y. Merhi, L. Bilodeau, O. Savadogo, L’H. Yahia (2000), “Effect of sterilization processes on thrombogenicity of NiTi stents in ex vivo model”, Shape Memory Implants, Ed. L’H. Yahia, Springer-Verlag, p. 253-266.

B. Thierry, M. Tabrizian (2001), “Biostability of metallic cardiovascular implants”, New acquistion of vascular biomaterials, Ed. Nabil Chakfé, pp.101-114.

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